Ethanol → HCID 69522445、化合物

HRID 456593

反応式

HRID 456593 の反応式
Br[CH2:2][C:3]1[CH:4]=[CH:5][C:6]2[C:7]([CH:11]=1)=[N:8][S:9][N:10]=2.C(O)C.[C-:15]#[N:16].[K+]>O>[N:10]1[S:9][N:8]=[C:7]2[CH:11]=[C:3]([CH2:2][C:15]#[N:16])[CH:4]=[CH:5][C:6]=12

参加物

5

反応物 3

HCID 702EthanolHCID 9032Potassium CyanideHCID 5910045-(Bromomethyl)-2,1,3-benzothiadiazole

生成物 1

HCID 69522445HCID 69522445、化合物収率 53.3%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A mixture of 5-bromomethyl-benzo[1,2,5]thiadiazole [RN65858-50-6](7.0 g, 30 mmol), ethanol (50 ml)and a solution of potassium cyanide (2.3 g, 36 mmol) in water (25 ml) was stirred at 50° C. for 15 hours. The alcoholic solution was concentrated and the residue suspended in water. The solid was collected by filtration, washed with water and dried in vacuo to give benzo[1,2,5]thiadiazol-5-yl-acetonitrile (2.8 g, 47%)

後処理

  1. concentrationThe alcoholic solution was concentrated
  2. filtrationThe solid was collected by filtration
  3. washwashed with water
  4. customdried in vacuo

出典と根拠

ORDレコード
ord-a391e509cf0c4b54be8190b45336aff2
出典データセット
uspto-grants-2007_03
特許番号
US07186730B2

関連ノート

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