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Tetrahydrofuran → 5-(2-Hydroxy-ethyl)-3H-benzoxazol-2-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Tetrahydrofuran | HCID 8028 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | Sulfuric acid magnesium salt (1:1) | HCID 24083 | — |
| 反応物 | Hydride | HCID 166653 | — |
| 反応物 | Aluminium lithium hydride | HCID 21226445 | — |
| 反応物 | 5-Cyanomethylbenz-2,1,3-thiadiazole | HCID 69522445 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 5-(2-Hydroxy-ethyl)-3H-benzoxazol-2-one | HCID 17981229 | 65% |
反応手順
Ester (a) (0.95 g, 4.29 mmol) was added portionwise to a cold solution (0° C.) of lithium aluminium hydride (0.206 g, 4.7 mmol) in tetrahydrofuran (20 ml). The mixture was then stirred 1.5 hours at room temperature and cooled again. The excess of hydride was hydrolysed by careful addition of water (0.2 ml), 5N aqueous sodium hydroxide solution (0.2 ml) and finally water (0.6 ml). Magnesium sulfate was added and the mixture was filtered. The filtrate was concentrated to dryness to give the product (0.5 g, 65%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07186730B2 |
| 出典データセット | uspto-grants-2007_03 |
| ORD ID | ord-b2a5bce6931b4469875ced99a3d86bcb |
| 出典メモ | uspto-grants-2007_03 |