Bromine → N-[4-(2-Bromoacetyl)Phenyl]Acetamide

HRID 45666

反応式

HRID 45666 の反応式
[C:1]([C:4]1[CH:9]=[CH:8][C:7]([NH:10][C:11](=[O:13])[CH3:12])=[CH:6][CH:5]=1)(=[O:3])[CH3:2].[Br:14]Br>C(O)(=O)C>[Br:14][CH2:2][C:1]([C:4]1[CH:9]=[CH:8][C:7]([NH:10][C:11](=[O:13])[CH3:12])=[CH:6][CH:5]=1)=[O:3]

参加物

4

反応物 2

HCID 24408BromineHCID 75937N-(p-acetylphenyl)acetamide

生成物 1

HCID 12364739N-[4-(2-Bromoacetyl)Phenyl]Acetamide

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒2 回

反応条件

温度
50 °C

実験手順

Into a 100-mL 3-necked round-bottom flask, was placed a solution of N-(4-acetylphenyl)acetamide (1 g, 5.65 mmol, 1.00 equiv) in acetic acid (10 mL). This was followed by the addition of a solution of bromine (910 mg, 5.69 mmol, 1.01 equiv) in acetic acid (2 mL) dropwise with stirring at 50° C. The resulting solution was stirred for 1.5 h at 50° C. The reaction was then quenched by the addition of 100 mL of water/ice. The solids were collected by filtration and dried under vacuum. This resulted in 0.5 g (33%) of N-(4-(2-bromoacetyl)phenyl)acetamide as a white solid.

後処理

  1. customInto a 100-mL 3-necked round-bottom flask, was placed
  2. stirringThe resulting solution was stirred for 1.5 h at 50° C
  3. customThe reaction was then quenched by the addition of 100 mL of water/ice
  4. filtrationThe solids were collected by filtration
  5. customdried under vacuum
  6. customThis resulted in 0.5 g (33%) of N-(4-(2-bromoacetyl)phenyl)acetamide as a white solid

出典と根拠

ORDレコード
ord-ba0c0b9a0fc242a0a344dbd86f34d9a5
出典データセット
uspto-grants-2013_09
特許番号
US08541448B2

関連ノート

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