1-[6-Bromo-2-(4-fluorophenyl)imidazo[1,2-a]pyridin-3-yl]-2-propyn-1-ol → 1-[6-Bromo-2-(4-fluorophenyl)imidazo[1,2-a]pyridin-3-yl]-2-propyn-1-one

HRID 456712

反応式

[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([C:8]([CH:18]([OH:21])[C:19]#[CH:20])=[C:9]([C:11]3[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=3)[N:10]=2)[CH:7]=1>[O-2].[Mn+6].[O-2].[O-2]>[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[N:6]([C:8]([C:18](=[O:21])[C:19]#[CH:20])=[C:9]([C:11]3[CH:12]=[CH:13][C:14]([F:17])=[CH:15][CH:16]=3)[N:10]=2)[CH:7]=1

参加物

実験手順

1-[6-bromo-2-(4-fluorophenyl)imidazo[1,2-a]pyridin-3-yl]-2-propyn-1-ol (2 g, 5.8 mmoles) was treated with manganese(VI)oxide in a similar manner as described in Example 2 to give, after filtration and silica gel chromatogaphy (2% methanol in dichloromethane), 1-[6-bromo-2-(4-fluorophenyl)imidazo[1,2-a]pyridin-3-yl]-2-propyn-1-one (1.2 g, 60%) as a solid. 1H NMR (CDCl3): δ 9.94 (s, 1H), 7.75 (m, 4H), 7.22 (t, 2H), 2.94 (s, 1H); 19F NMR (CDCl3) δ −111.3.

後処理

customto give
filtrationafter filtration and silica gel chromatogaphy (2% methanol in dichloromethane), 1-[6-bromo-2-(4-fluorophenyl)imidazo[1,2-a]pyridin-3-yl]-2-propyn-1-one (1.2 g, 60%) as a solid

出典と根拠

ORDレコード: ord-0335fe8c0d64476c9daab5ec753b9f7d
出典データセット: uspto-grants-2007_03
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07186714B2

反応式

参加物

反応物 1

生成物 1

試薬・触媒・溶媒 1

実験手順

後処理

出典と根拠

関連ノート