Hydrochloric Acid → 1-Benzyl-4-methylpiperidin-4-amine
反応式
[CH2:1]([N:8]1[CH2:13][CH2:12][C:11]([NH:15]C(=O)C)([CH3:14])[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl>>[CH2:1]([N:8]1[CH2:13][CH2:12][C:11]([CH3:14])([NH2:15])[CH2:10][CH2:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1参加物
3
実験手順
A mixture of N-(1-benzyl-4-methyl-4-piperidinyl)acetamide obtained in Example 10-2 (3.45 g) and conc. HCl (41 mL) was heated under reflux with stirring for 72 hrs. After cooling, the mixture was quenched by adding 3N potassium hydroxide solution, and the resulting solution (pH11) was extracted with chloroform. The organic layer was washed with brine, dried over MgSO4, and concentrated to give the title compound as a pale brown oil (2.86 g).
後処理
- temperaturewas heated
- temperatureunder reflux
- temperatureAfter cooling
- customthe mixture was quenched
- additionby adding 3N potassium hydroxide solution
- extractionthe resulting solution (pH11) was extracted with chloroform
- washThe organic layer was washed with brine
- dry with materialdried over MgSO4
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-13b9a379efaa49a4be83c134ec18a6cd
- 出典データセット
- uspto-grants-2007_03
- 特許番号
- US07186731B2
反応ノート
読み込み中…