化工社化工社 化学情報印刷レポート · 研究参考用
Dimethylformamide → N-methoxy-N-methyl-4-nitrobenzamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dimethylformamide | HCID 6228 | — |
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 4-Nitrobenzoyl chloride | HCID 8502 | — |
| 触媒 | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | N-methoxy-N-methyl-4-nitrobenzamide | HCID 2991007 | — |
反応手順
N,O-(Dimethyl)hydroxylamine hydrochloride (6.45 g, 65.8 mmol), triethylamine (20 ml, 145 mmol) and 4-dimethylaminopyridine (300 mg, 2.5 mmol) were suspended in 150 ml of DMF at 0° C. 4-Nitrobenzoyl chloride (10 g, 53.8 mmol) was added. After 1.5 hours at 0° C., the mixture was diluted with ethyl acetate, washed with 1M HCl and then sat. NaCl and dried over sodium sulfate. Filtration and evaporation gave the title compound as a light yellow solid (8.51 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07186738B2 |
| 出典データセット | uspto-grants-2007_03 |
| ORD ID | ord-7b96452c4f8e45709bd04a0e9842b974 |
| 出典メモ | uspto-grants-2007_03 |