化工社化工社 化学情報印刷レポート · 研究参考用
Potassium Hydroxide → 4-Methoxy-2-(prop-2-en-1-yloxy)benzoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Hydroxide | HCID 14797 | — |
| 反応物 | Methyl 2-(allyloxy)-4-methoxybenzoate | HCID 10242646 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | 4-Methoxy-2-(prop-2-en-1-yloxy)benzoic acid | HCID 21506878 | — |
反応手順
To a solution of 2 (2.5 g, 11 mmol) in aqueous methanol (30 mL) was added KOH (1 eq, 630 mg). Reaction was heated to 50° C. for 12 hours before the addition of more KOH (630 mg). After 12 hours, the mixture was cooled, diluted with EtOAc and washed with 1M HCl. Aqueous layer was extracted with EtOAc (3×). Combined organic layers, dried over Na2SO4, and concentrated. Product was isolated as an off white solid and used without further purification.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07186746B2 |
| 出典データセット | uspto-grants-2007_03 |
| ORD ID | ord-7a610adfa43f42618315f674ee0c8a30 |
| 出典メモ | uspto-grants-2007_03 |