Citric Acid → 2-Chloro-5-(5-cyclopropyl-1H-pyrazol-3-yl)-benzoic acid

HRID 456876ノート

反応式

HRID 456876 の反応式
C([O:3][C:4](=[O:20])[C:5]1[CH:10]=[C:9]([C:11]2[CH:15]=[C:14]([CH:16]3[CH2:18][CH2:17]3)[NH:13][N:12]=2)[CH:8]=[CH:7][C:6]=1[Cl:19])C.[OH-].[K+].C(O)(=O)CC(CC(O)=O)(C(O)=O)O>CO>[Cl:19][C:6]1[CH:7]=[CH:8][C:9]([C:11]2[CH:15]=[C:14]([CH:16]3[CH2:17][CH2:18]3)[NH:13][N:12]=2)=[CH:10][C:5]=1[C:4]([OH:20])=[O:3]

参加物

5

反応物 3

HCID 311Citric AcidHCID 14797Potassium HydroxideHCID 588181832-chloro-5-(5-cyclopropyl-1H-pyrazol-3-yl)-benzoic acid ethyl ester

生成物 1

HCID 184386582-Chloro-5-(5-cyclopropyl-1H-pyrazol-3-yl)-benzoic acid収率 134.4%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a solution of 2-chloro-5-(5-cyclopropyl-1H-pyrazol-3-yl)-benzoic acid ethyl ester (0.05 g, 0.17 mmol) in methanol (4 mL) was added KOH (0.12 g). The mixture was shaken at room temperature for 16 h. The mixture was acidified with 10% aqueous citric acid and extracted with ethyl acetate. The combined organic layers were washed with water and brine, and concentrated in vacuo to afford the title compound (0.06 g).

後処理

  1. extractionextracted with ethyl acetate
  2. washThe combined organic layers were washed with water and brine
  3. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-16b5ee0b06a4425e8cdaa2cc686595d7
出典データセット
uspto-grants-2007_03
特許番号
US07186742B2

反応ノート

読み込み中…