Hydrochloric Acid → 2-Chloro-5-(2H-[1,2,3]triazol-4-yl)-benzoic acid
反応式
C[O:2][C:3](=[O:16])[C:4]1[CH:9]=[C:8]([C:10]2[CH:14]=[N:13][NH:12][N:11]=2)[CH:7]=[CH:6][C:5]=1[Cl:15].[OH-].[K+].Cl>CO>[Cl:15][C:5]1[CH:6]=[CH:7][C:8]([C:10]2[CH:14]=[N:13][NH:12][N:11]=2)=[CH:9][C:4]=1[C:3]([OH:16])=[O:2]参加物
5
実験手順
To a solution of 2-chloro-5-(2H-[1,2,3]triazol-4-yl)-benzoic acid methyl ester (0.095 g, 0.4 mmol) in methanol (2 mL) was added potassium hydroxide (0.25 g). The mixture was shaken at room temperature for 12 h. The mixture was diluted with methanol and acidified with HCl (2 mL, 6M). The mixture was concentrated in vacuo, diluted with water and sonicated. The solids were collected by filtration and washed with hexanes to afford the title compound (0.075 g).
後処理
- concentrationThe mixture was concentrated in vacuo
- additiondiluted with water
- customsonicated
- filtrationThe solids were collected by filtration
- washwashed with hexanes
出典と根拠
- ORDレコード
- ord-d374b67a55a2461282f8bd990dcc0692
- 出典データセット
- uspto-grants-2007_03
- 特許番号
- US07186742B2
反応ノート
読み込み中…