Bromine → 5-(2-Bromo-acetyl)-2-chloro-benzoic acid methyl ester

HRID 456891ノート

反応式

HRID 456891 の反応式
[CH3:1][O:2][C:3](=[O:14])[C:4]1[CH:9]=[C:8]([C:10](=[O:12])[CH3:11])[CH:7]=[CH:6][C:5]=1[Cl:13].[Br:15]Br>C(O)(=O)C.Br.C(O)(=O)C>[CH3:1][O:2][C:3](=[O:14])[C:4]1[CH:9]=[C:8]([C:10](=[O:12])[CH2:11][Br:15])[CH:7]=[CH:6][C:5]=1[Cl:13]

参加物

5

反応物 2

HCID 24408BromineHCID 58818179Methyl 5-acetyl-2-chlorobenzoate

生成物 1

HCID 588181855-(2-Bromo-acetyl)-2-chloro-benzoic acid methyl ester収率 102.2%

試薬・触媒・溶媒 2

HCID 21893785Acetic Acid Mixture with Hydrobromic Acid触媒HCID 176Acetic Acid溶媒

実験手順

To a solution of 5-acetyl-2-chloro-benzoic acid methyl ester (100 mg, 0.47 mmol) in glacial acetic acid (5 mL) was added bromine (0.05 mL, 0.94 mmol). The mixture was stirred at room temperature for 2 h. Hydrobromic acid-acetic acid (2 drops, 30%) was added and the mixture was stirred for 10 minutes. The mixture was concentrated in vacuo to afford the title compound (140 mg).

後処理

  1. stirringthe mixture was stirred for 10 minutes
  2. concentrationThe mixture was concentrated in vacuo

出典と根拠

ORDレコード
ord-7d952decae654fb691265f7365789614
出典データセット
uspto-grants-2007_03
特許番号
US07186742B2

反応ノート

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