Water → 2,5-Difluoro-4-(pyrrol-1-yl)benzoic acid

HRID 4569ノート

反応式

HRID 4569 の反応式
[F:1][C:2]1[CH:10]=[C:9]([NH2:11])[C:8]([F:12])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].CO[C:15]1(OC)[CH2:19][CH2:18][CH2:17]O1.O>C(O)(=O)C>[F:1][C:2]1[CH:10]=[C:9]([N:11]2[CH:15]=[CH:19][CH:18]=[CH:17]2)[C:8]([F:12])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5]

参加物

5

反応物 3

HCID 962WaterHCID 11788317DimethoxytetrahydrofuraneHCID 201514774-Amino-2,5-difluorobenzoic acid

生成物 1

HCID 201514742,5-Difluoro-4-(pyrrol-1-yl)benzoic acid収率 79.2%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

5.2 grams (0.03 mol) of 2,5-difluoro-4-aminobenzoic acid, melting at 250°-3°, are dissolved in 60 ml of glacial acetic acid, and 4 grams (0.03 mol) of dimethoxytetrahydrofuran are added. The mixture is heated at the boil for 10 minutes, 20 ml of water are added and the resulting mixture is left to cool. The precipitate formed is filtered off and washed with water to give 5.3 grams of a solid melting at 196°-8° C.

後処理

  1. temperatureThe mixture is heated at the boil for 10 minutes
  2. waitthe resulting mixture is left
  3. temperatureto cool
  4. customThe precipitate formed
  5. filtrationis filtered off
  6. washwashed with water

出典と根拠

ORDレコード
ord-dc223d62d465498286c60c57753211e7
出典データセット
uspto-grants-1988_02
特許番号
US04727080

反応ノート

読み込み中…