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6-Methoxy-2-methylsulfanyl-quinoline → 2-Methanesulfonyl-6-methoxy-quinoline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 6-Methoxy-2-methylsulfanyl-quinoline | HCID 11241182 | — |
| 反応物 | MeOH tetrahydrofuran | HCID 21899815 | — |
| 反応物 | Potassium hydroxy sulfite | HCID 23707502 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 2-Methanesulfonyl-6-methoxy-quinoline | HCID 11253377 | — |
反応手順
A solution of 6-methoxy-2-methylsulfanyl-quinoline (1.0 g, 5 mmoles) in 100 mL 1:1 MeOH/THF was treated with a solution of 5 g OXONE™ in 50 mL water and stirred for 2–3 hours until the oxidation is complete. The mixture is poured into water and extracted with EtOAc. The organic phase is dried and evaporated to yield 2-methanesulfonyl-6-methoxy-quinoline as a crystalline white product.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07186840B2 |
| 出典データセット | uspto-grants-2007_03 |
| ORD ID | ord-97a0ad9152da4e2d945150aacb685751 |
| 出典メモ | uspto-grants-2007_03 |