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Sodium Chloride → 5-(2,4-Difluoro-phenylsulfanyl)-2-methanesulfonyl-6-methoxy-quinoline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Chloride | HCID 5234 | — |
| 反応物 | Bis(trifluoroacetoxy)iodobenzene | HCID 102317 | — |
| 反応物 | 2,4-Difluorobenzene-1-thiol | HCID 2737073 | — |
| 反応物 | 2-Methanesulfonyl-6-methoxy-quinoline | HCID 11253377 | — |
| 生成物 | 5-(2,4-Difluoro-phenylsulfanyl)-2-methanesulfonyl-6-methoxy-quinoline | HCID 9864712 | — |
反応手順
A solution of 2-methanesulfonyl-6-methoxy-quinoline (237 mg, 1 mmole) and 2,4-difluorobenzenethiol (296 mg, 2 mmoles) was treated with PIFA (645 mg, 1.5 mmoles) and stirred for 30 min. The solution was poured into dilute NaCl solution and extracted with ethyl acetate (EtOAc). The organic layer was dried (MgSO4) and evaporated. The resulting oil was crystallized to yield 5-(2,4-difluoro-phenylsulfanyl)-2-methanesulfonyl-6-methoxy-quinoline 101.; ([M+H]+)=382 The yield is typically 80–90%.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07186840B2 |
| 出典データセット | uspto-grants-2007_03 |
| ORD ID | ord-0466bb86afb243ab8565a782628806f3 |
| 出典メモ | uspto-grants-2007_03 |