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Bromine → 5-Bromo-2-methanesulfonyl-6-methoxy-quinoline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Bromine | HCID 24408 | — |
| 反応物 | Sodium Thiosulfate | HCID 24477 | — |
| 反応物 | Sodium Bicarbonate | HCID 516892 | — |
| 反応物 | 2-Methanesulfonyl-6-methoxy-quinoline | HCID 11253377 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 5-Bromo-2-methanesulfonyl-6-methoxy-quinoline | HCID 22139732 | — |
反応手順
A solution of 2-methanesulfonyl-6-methoxy-quinoline (237 mg, 1 mmole ) in CH2Cl2 was treated with 2 mmoles Br2 and stirred for 1 day. The mixture was poured into a solution of NaHCO3 and sodium thiosulfate. The product was extracted with CH2Cl2. The organic layer was dried and evaporated to afford 5-bromo-2-methanesulfonyl-6-methoxy-quinoline, 287 mg (91%), as white crystals.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07186840B2 |
| 出典データセット | uspto-grants-2007_03 |
| ORD ID | ord-e1f3bbba8e15440082e249eeef0fb0a8 |
| 出典メモ | uspto-grants-2007_03 |