1-Methyl-3-{N-[beta-(3,4-dipivalyloxyphenyl)ethyl]}carbamoyl-1,4-dihydropyridine → 1-Methyl-3-{N-[beta-(4-hydroxy-3-methoxyphenyl)ethyl]}carbamoyl-1,4-dihydropyridine

HRID 4575ノート

反応式

HRID 4575 の反応式
[CH3:1][N:2]1[CH:7]=[CH:6][CH2:5][C:4]([C:8](=[O:32])[NH:9][CH2:10][CH2:11][C:12]2[CH:17]=[CH:16][C:15]([O:18]C(=O)C(C)(C)C)=[C:14]([O:25][C:26](=O)C(C)(C)C)[CH:13]=2)=[CH:3]1.[2H]C(Cl)(Cl)Cl.[2H]O[2H]>>[CH3:1][N:2]1[CH:7]=[CH:6][CH2:5][C:4]([C:8](=[O:32])[NH:9][CH2:10][CH2:11][C:12]2[CH:17]=[CH:16][C:15]([OH:18])=[C:14]([O:25][CH3:26])[CH:13]=2)=[CH:3]1

参加物

3

反応物 2

HCID 100720521-Methyl-3-{N-[beta-(3,4-dipivalyloxyphenyl)ethyl]}carbamoyl-1,4-dihydropyridineHCID 86585196CDCl3 D2O

生成物 1

HCID 140504291-Methyl-3-{N-[beta-(4-hydroxy-3-methoxyphenyl)ethyl]}carbamoyl-1,4-dihydropyridine

実験手順

This compound was prepared following the same method as for the preparation of compound 5c. The crude solid obtained showed the same NMR (CDCl3 /D2O) pattern as compound 5a, except for a peak at δ 3.5 for the OCH3 protons. It was sufficiently pure for the determination of its retention time following the HPLC method of analysis detailed in EXAMPLE 18 below. No trials were made for its further crystallization or elemental analysis.

後処理

  1. customThis compound was prepared
  2. customThe crude solid obtained
  3. customNo trials were made for its further crystallization or elemental analysis

出典と根拠

ORDレコード
ord-c54d5e7c4e7f4a898b89558681cf48a2
出典データセット
uspto-grants-1988_02
特許番号
US04727079

反応ノート

読み込み中…