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1,4-Cyclohexanedimethanamine → N'-[4-(aminomethyl)cyclohexyl]methyl-N,N-dimethylsulfamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1,4-Cyclohexanedimethanamine | HCID 17354 | — |
| 反応物 | Diisopropylethylamine | HCID 81531 | — |
| 反応物 | Dimethylsulphamoyl chloride | HCID 83372 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | N'-[4-(aminomethyl)cyclohexyl]methyl-N,N-dimethylsulfamide | HCID 22254077 | — |
反応手順
Dimethylsulfamoyl chloride (one mol-equivalent, ClSO2N(CH3)2) was added to a stirred solution of 1,4-bis-aminomethylcyclohexane (3 mol-equivalents) and diisopropylethylamine (1 mol-equivalent) in dichloromethane at 0° C. The reaction mixture was stirred at room temperature for 24 hours, concentrated under reduced pressure and chromatographed (silica) to give the desired product as viscous oils. (Scheme 1A).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07189720B2 |
| 出典データセット | uspto-grants-2007_03 |
| ORD ID | ord-5e70ce1d4c6c492c8f28d8f2334634c4 |
| 出典メモ | uspto-grants-2007_03 |