関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Pyridine | HCID 1049 | — |
| 反応物 | 2-Fluorobenzoyl chloride | HCID 9808 | — |
| 反応物 | 2-Amino-5-bromobenzamide | HCID 5019271 | — |
| 溶媒 | Chloroform | HCID 6212 | — |
| 生成物 | 2-(2-Fluorobenzoyl)-amino-5-bromo-benzamide | HCID 18440639 | 57.4% |
反応手順
2-Amino-5-bromo-benzamide (2 g, 9.3 mmol) was dissolved in chloroform (40 ml) in a 50 ml round bottomed flask and cooled to 0° C. Pyridine (0.8 ml, 9.3 mmol) was added followed by 2-fluoro-benzoyl chloride (1.3 ml, 10 mmol) and the mixture was magnetically stirred for 1 hr at this temperature. 10% Hydrochloric acid (50 ml) was added and the precipitated solid was filtered, washed with water and dried to yield pure title compound (1.8 g, 57%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07189733B2 |
|---|
| 出典データセット | uspto-grants-2007_03 |
|---|
| ORD ID | ord-f94ac6a08766449cb5c084e38556efe9 |
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| 出典メモ | uspto-grants-2007_03 |
|---|
