1,4-Dibromonaphthalene → 4-Bromo-1-naphthonitrile
反応式
Br[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]([Br:12])=[CH:4][CH:3]=1.[Cu](C#N)[C:14]#[N:15]>CN(C=O)C>[Br:12][C:5]1[C:6]2[C:11](=[CH:10][CH:9]=[CH:8][CH:7]=2)[C:2]([C:14]#[N:15])=[CH:3][CH:4]=1参加物
4
反応条件
- 温度
- 125 °C
実験手順
A mixture of 1,4-dibromonaphthalene (24.06 g, 84 mmol) and copper cyanide (6.02 g, 67 mmol) in DMF (85 mL) was heated to 125° C. overnight. The mixture was partially concentrated to remove DMF and the resulting residue washed with aqueous ammonium hydroxide and extracted with ethyl acetate. The organic layer was concentrated and purified by chromatography to yield 4-bromo-1-naphthonitrile (5.13 g, 26%).
後処理
- concentrationThe mixture was partially concentrated
- customto remove DMF
- washthe resulting residue washed with aqueous ammonium hydroxide
- extractionextracted with ethyl acetate
- concentrationThe organic layer was concentrated
- custompurified by chromatography
出典と根拠
- ORDレコード
- ord-f59ca2945eba4b08beec8ffdabe7efe7
- 出典データセット
- uspto-grants-2013_09
- 特許番号
- US08541589B2
反応ノート
読み込み中…