化工社化工社 化学情報印刷レポート · 研究参考用
6-Fluoroindole → 6-fluoro-3-(piperidin-4-yl)-1H-indole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 6-Fluoroindole | HCID 351278 | — |
| 反応物 | Piperonylamine | HCID 2723901 | — |
| 触媒 | Adams' catalyst | HCID 345198 | — |
| 生成物 | 6-fluoro-3-(piperidin-4-yl)-1H-indole | HCID 11096077 | 51% |
反応手順
This compound was prepared following the procedure described in example 1 (parts A and B) starting with 1 g (7.4 mmol) of 6-fluoroindol and 2.84 g (18.5 mmol) of 4-piperidone monohydrate hydrochloride. In this case, the hydrogenation step took place for 1 hour at 30 psi and the catalyst used was platinum (IV) oxide. 0.640 g (51% yield) of 6-fluoro-3-piperidin-4-yl-1H-indole were obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07189741B2 |
| 出典データセット | uspto-grants-2007_03 |
| ORD ID | ord-a88e4eccea67484fb2055c509818042c |
| 出典メモ | uspto-grants-2007_03 |