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2-(Bromomethyl)furan → 4-(6-fluoro-1-furan-2-ylmethyl-1H-indol-3-yl)-piperidine-1-carboxylic acid ethyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-(Bromomethyl)furan | HCID 4603765 | — |
| 反応物 | 4-(6-fluoro-1H-indol-3-yl)-piperidine-1-carboxylic acid ethyl ester | HCID 11323738 | — |
| 生成物 | 4-(6-fluoro-1-furan-2-ylmethyl-1H-indol-3-yl)-piperidine-1-carboxylic acid ethyl ester | HCID 11349225 | 100.5% |
反応手順
This compound was obtained following procedure described in example 13 (part B) at room temperature for 5 hours, starting with 5 g (17.2 mmol) of 4-(6-fluoro-1H-indol-3-yl)-piperidine-1-carboxylic acid ethyl ester were and 3.2 g (20 mmol) of 2-bromomethyl-furan. After standard work-up, 6.4 g (99% of yield) of 4-(6-fluoro-1-furan-2-ylmethyl-1H-indol-3-yl)-piperidine-1-carboxylic acid ethyl ester were obtained.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07189741B2 |
| 出典データセット | uspto-grants-2007_03 |
| ORD ID | ord-b6b8cf0fc646427497229658acfff45a |
| 出典メモ | uspto-grants-2007_03 |