Methyl 3-(bromomethyl)benzoate → 3-{4-[1-(5-Chloro-thiophen-2-ylmethyl)-1H-indol-3-yl]-piperidin-1-ylmethyl}-benzoic acid

HRID 457801

反応式

HRID 457801 の反応式
[Cl:1][C:2]1[S:6][C:5]([CH2:7][N:8]2[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[C:10]([CH:17]3[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]3)=[CH:9]2)=[CH:4][CH:3]=1.C[O:24][C:25](=[O:34])[C:26]1[CH:31]=[CH:30][CH:29]=[C:28]([CH2:32]Br)[CH:27]=1>>[Cl:1][C:2]1[S:6][C:5]([CH2:7][N:8]2[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[C:10]([CH:17]3[CH2:22][CH2:21][N:20]([CH2:32][C:28]4[CH:27]=[C:26]([CH:31]=[CH:30][CH:29]=4)[C:25]([OH:34])=[O:24])[CH2:19][CH2:18]3)=[CH:9]2)=[CH:4][CH:3]=1

参加物

3

反応物 2

HCID 517981Methyl 3-(bromomethyl)benzoateHCID 113709341-(5-chloro-thiophen-2-ylmethyl)-3-piperidin-4-yl-1H-indole

生成物 1

HCID 102051213-{4-[1-(5-Chloro-thiophen-2-ylmethyl)-1H-indol-3-yl]-piperidin-1-ylmethyl}-benzoic acid

実験手順

This compound was prepared following the procedure described in example 19 (part C) starting with 1.48 mmol (4.48 mmol) of 1-(5-chloro-thiophen-2-ylmethyl)-3-piperidin-4-yl-1H-indole and 1.0 g (8.8 mmol) of 3-bromomethyl-benzoic acid methyl ester. The crude mixture was purified by flash chromatography over silica gel affording 0.29 g (14% of yield) of the pure acid.

後処理

  1. customThis compound was prepared
  2. customThe crude mixture was purified by flash chromatography over silica gel affording 0.29 g (14% of yield) of the pure acid

出典と根拠

ORDレコード
ord-5d653f455822488980d936ec3843bf98
出典データセット
uspto-grants-2007_03
特許番号
US07189741B2

関連ノート

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