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HRID 457813作成日：2026年10月25日

3-(Chloromethyl)pyridine hydrochloride → 2-[4-(1-pyridin-3-ylmethyl-1H-indol-3-yl)-piperidin-1-ylmethyl]-nicotinic Acid

https://huagongshe.com/reaction/457813

反応式

関与物質

役割名称HCID仕込み量
反応物3-(Chloromethyl)pyridine hydrochlorideHCID 23394—
反応物2-[4-(1H-indol-3-yl)-piperidin-1-ylmethyl]-nicotinic acid ethyl esterHCID 69411779—
生成物2-[4-(1-pyridin-3-ylmethyl-1H-indol-3-yl)-piperidin-1-ylmethyl]-nicotinic AcidHCID 10159516—

反応手順

This compound was prepared following the procedure described in example 1 (part E) starting with 0.76 g (0.21 mmol) of 2-[4-(1H-indol-3-yl)-piperidin-1-ylmethyl]-nicotinic acid ethyl ester and 0.04 g (0.25 mmol) of 3-chloromethyl-pyridine hydrochloride. After standard purification, 0.040 g (45% of yield) of the expected acid were obtained.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US07189741B2
出典データセットuspto-grants-2007_03
ORD IDord-d806986ba8bd4db58d3712c538a6cf22
出典メモuspto-grants-2007_03