2-(2-Thienyl)ethyl methanesulphonate → 2-methoxy-5-{4-[1-(2-thiophen-2-yl-ethyl)-1H-indol-3-yl]-piperidin-1-ylmethyl}-benzoic acid

HRID 457816

反応式

HRID 457816 の反応式
C([O:3][C:4](=[O:29])[C:5]1[CH:10]=[C:9]([CH2:11][N:12]2[CH2:17][CH2:16][CH:15]([C:18]3[C:26]4[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=4)[NH:20][CH:19]=3)[CH2:14][CH2:13]2)[CH:8]=[CH:7][C:6]=1[O:27][CH3:28])C.CS(O[CH2:35][CH2:36][C:37]1[S:38][CH:39]=[CH:40][CH:41]=1)(=O)=O>>[CH3:28][O:27][C:6]1[CH:7]=[CH:8][C:9]([CH2:11][N:12]2[CH2:17][CH2:16][CH:15]([C:18]3[C:26]4[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=4)[N:20]([CH2:35][CH2:36][C:37]4[S:38][CH:39]=[CH:40][CH:41]=4)[CH:19]=3)[CH2:14][CH2:13]2)=[CH:10][C:5]=1[C:4]([OH:3])=[O:29]

参加物

3

反応物 2

HCID 30477232-(2-Thienyl)ethyl methanesulphonateHCID 694122085-[4-(1H-indol-3-yl)-piperidin-1-ylmethyl]-2-methoxy-benzoic acid ethyl ester

生成物 1

HCID 102273262-methoxy-5-{4-[1-(2-thiophen-2-yl-ethyl)-1H-indol-3-yl]-piperidin-1-ylmethyl}-benzoic acid

実験手順

This compound was prepared following the procedure described in example 1 (part E) starting with 0.07 g (0.18 mmol) of 5-[4-(1H-indol-3-yl)-piperidin-1-ylmethyl]-2-methoxy-benzoic acid ethyl ester and 0.05 g (0.25 mmol) of 2-thiophen-2-yl-ethyl methansulfonate. After the standard purification, 0.009 g (10% of yield) of the expected acid was obtained.

後処理

  1. customThis compound was prepared
  2. customAfter the standard purification, 0.009 g (10% of yield) of the expected acid
  3. customwas obtained

出典と根拠

ORDレコード
ord-6c3f8dd98f1e4f999960ce66f9e96ae7
出典データセット
uspto-grants-2007_03
特許番号
US07189741B2

関連ノート

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