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O-((4-Methoxyphenyl)methyl)hydroxylamine → Tert-butoxycarbonyl-4-{[(4-methoxybenzyl)oxy]imino}-2-pyrrolidine-carboxylic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | O-((4-Methoxyphenyl)methyl)hydroxylamine | HCID 120426 | — |
| 反応物 | (2S)-1-(tert-butoxycarbonyl)-4-oxopyrrolidine-2-carboxylic acid | HCID 11593804 | — |
| 反応物 | tert-butoxycarbonyl-4-(methoxyimino)-2-Pyrrolidinecarboxylic acid | HCID 72828956 | — |
| 生成物 | Tert-butoxycarbonyl-4-{[(4-methoxybenzyl)oxy]imino}-2-pyrrolidine-carboxylic acid | HCID 73876899 | 85% |
反応手順
The same method as employed in the preparation of Intermediate 7, but starting from (2S)-1-(tert-butoxycarbonyl)-4-oxo-2-pyrrolidinecarboxylic acid (Intermediate 1) and 1[(aminooxy)methyl]-4-methoxy-benzene (Intermediate 10) gave the title compound as a gum in a 85% yield.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07189754B2 |
| 出典データセット | uspto-grants-2007_03 |
| ORD ID | ord-235e92cbb3e34fcf9cf44aa06c42ac6b |
| 出典メモ | uspto-grants-2007_03 |