Methanol → Methyl (2S,4EZ)-1-[(2'-chloro[1,1'-biphenyl]-4-yl)carbonyl]-4-(methoxyimino)-2-pyrrolidinecarboxylate

関与物質

役割	名称	HCID	仕込み量
反応物	Methanol	HCID 887	—
反応物	F 1893	HCID 160722	—
反応物	(2S,4EZ)-1(tert-butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid	HCID 58714586	—
生成物	Methyl (2S,4EZ)-1-[(2'-chloro[1,1'-biphenyl]-4-yl)carbonyl]-4-(methoxyimino)-2-pyrrolidinecarboxylate	HCID 131726290	—

反応手順

Following the general method as outlined in Example 11, starting from (2S,4EZ)-1-(tert-butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, 2′-chloro[1,1′-biphenyl]-4-carboxylic acid, and methanol, the title compound isolated as a mixture of two isomers in 92.3% purity by HPLC.

情報源と証拠

DOI	10.6084/m9.figshare.5104873.v1
特許番号	US07189754B2
出典データセット	uspto-grants-2007_03
ORD ID	ord-7cf9884824c74a34b2132ec3b1493bf2
出典メモ	uspto-grants-2007_03