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HRID 457932作成日：2026年10月25日

Methanol → Methyl (2S,4EZ)-4-(methoxyimino)-1-{[2'-(trifluoromethyl)[1,1'-biphenyl]-4-yl]carbonyl}-2-pyrrolidinecarboxylate

https://huagongshe.com/reaction/457932

反応式

関与物質

役割名称HCID仕込み量
反応物MethanolHCID 887—
反応物2'-Trifluoromethyl (1,1'-biphenyl)-4-carboxylic acidHCID 2782714—
反応物(2S,4EZ)-1(tert-butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acidHCID 58714586—
生成物Methyl (2S,4EZ)-4-(methoxyimino)-1-{[2'-(trifluoromethyl)[1,1'-biphenyl]-4-yl]carbonyl}-2-pyrrolidinecarboxylateHCID 131726292—

反応手順

Following the general method as outlined in Example 11, starting from (2S,4EZ)-1-(tert-butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, 2′-(trifluoromethyl)[1,1′-biphenyl]-4-carboxylic acid, and methanol, the title compound was isolated as a mixture of two isomers in 86.3% purity by HPLC.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US07189754B2
出典データセットuspto-grants-2007_03
ORD IDord-945aee578b904e09903dc6b30a78fbb3
出典メモuspto-grants-2007_03