関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Ethanol | HCID 702 | — |
| 反応物 | 2-Butenoic acid, 3-amino-, ethyl ester, (2Z)- | HCID 643756 | — |
| 反応物 | 2-(4-Acetylaminophenoxy)ethyl 2-(3-nitrobenzylidene)acetylacetate | HCID 57315737 | — |
| 生成物 | 2-(4-Acetylaminophenoxy)ethyl 2,6-dimethyl-5-ethoxycarbonyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate | HCID 20151208 | 75% |
反応手順
12.28 g (0.03 moles) of 2-(4-acetylaminophenoxy)ethyl 2-(3-nitrobenzylidene)acetylacetate and 3.85 (0.03 moles) of ethyl 3-aminocrotonate are heated under reflux in 30 ml of ethanol for 8 hours. The solution is then cooled to -5° C. to obtain 2-(4-acetylaminophenoxy)ethyl 2,6-dimethyl-5-ethoxycarbonyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate as yellow crystals melting--after recrystallisation in ethanol--at 198°-200° C. The yield is 75% of the theoretical yield.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04727066 |
|---|
| 出典データセット | uspto-grants-1988_02 |
|---|
| ORD ID | ord-dc1538eb82734bd38e7cfa4b9f6cdea5 |
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| 出典メモ | uspto-grants-1988_02 |
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