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Potassium Carbonate → Methyl (2S)-2-(2,3,4-trifluoroanilino)propionate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 2,3,4-Trifluoroaniline | HCID 77468 | — |
| 反応物 | Methyl 2-chloropropanoate, (R)- | HCID 149593 | — |
| 触媒 | Tetrahexylammonium chloride | HCID 80021 | — |
| 生成物 | Methyl (2S)-2-(2,3,4-trifluoroanilino)propionate | HCID 10125210 | — |
反応手順
In accordance with the process of Example 2, a condensation reaction was performed by using 2,3,4-trifluoroaniline (100 mg), potassium carbonate (188 mg), methyl (2R)-chloropropionate (92 mg) and tetrahexylammonium chloride (40 mg). As the result of the analysis by reversed phase HPLC with the use of the compound of Example 1 as a specimen, the product corresponded to 56 mg (36%) of the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07189847B2 |
| 出典データセット | uspto-grants-2007_03 |
| ORD ID | ord-fa10b7da2f6c432c96677422272918ed |
| 出典メモ | uspto-grants-2007_03 |