Hydrochloric Acid → (2S)-2-(2,3,4-trifluoroanilino)propionic acid

HRID 458175

反応式

HRID 458175 の反応式
[F:1][C:2]1[C:13]([F:14])=[C:12]([F:15])[CH:11]=[CH:10][C:3]=1[NH:4][C@@H:5]([CH3:9])[C:6]([OH:8])=[O:7].C1([C@@H](N)C)C=CC=CC=1.Cl>>[F:1][C:2]1[C:13]([F:14])=[C:12]([F:15])[CH:11]=[CH:10][C:3]=1[NH:4][C@@H:5]([CH3:9])[C:6]([OH:8])=[O:7]

参加物

3

反応物 2

HCID 313Hydrochloric AcidHCID 67369703HCID 67369703、化合物

生成物 1

HCID 67366567(2S)-2-(2,3,4-trifluoroanilino)propionic acid収率 96%

実験手順

To (2S)-2-(2,3,4-trifluoroanilino)propionic acid•(S)-1-phenylethylamine salt (1.0 g; 99% ee) were added IPE (20 ml) and hydrochloric acid (1 mol/l) until the pH value reached 1 and the resultant mixture was stirred at room temperature for 1 hour. The organic layer was dried over anhydrous magnesium sulfate. After evaporating the solvent, 618 mg of the title compound was obtained as colorless crystals. The optical purity of this product was 99% ee. The 1H-NMR and IR spectral data of this product was identical with those of the compound obtained in Example 23.

後処理

  1. dry with materialThe organic layer was dried over anhydrous magnesium sulfate
  2. customAfter evaporating the solvent

出典と根拠

ORDレコード
ord-13c76af55b6d416fb24bc04ff8a3e530
出典データセット
uspto-grants-2007_03
特許番号
US07189847B2

関連ノート

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