関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Ethanol | HCID 702 | — |
| 反応物 | 2-(4-Acetylaminophenoxy)ethyl 2-(3-nitrobenzylidene)acetylacetate | HCID 57315737 | — |
| 反応物 | 2-Ethylthioethyl 3-aminocrotonate | HCID 86741408 | — |
| 生成物 | 2-(4-Acetylaminophenoxy)ethyl 2,6-dimethyl-5-(2-ethylthioethoxycarbonyl)-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate | HCID 20151264 | 60% |
反応手順
15 g (0.04 moles) of 2-(4-acetylaminophenoxy)ethyl 2-(3-nitrobenzylidene)acetylacetate and 6.88 g (0.04 moles) of 2-ethylthioethyl 3-aminocrotonate were heated under reflux in 35 ml of ethanol for 8 hours. The solution was then cooled to -5° C. to obtain 2-(4-acetylaminophenoxy)ethyl 2,6-dimethyl-5-(2-ethylthioethoxycarbonyl)-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate as a yellow powder melting--after recrystallisation in ethanol--at 100°-104° C. The yield is 60% of the theoretical yield.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04727066 |
|---|
| 出典データセット | uspto-grants-1988_02 |
|---|
| ORD ID | ord-0762afb0cbd843a58951b15e1705bb6e |
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| 出典メモ | uspto-grants-1988_02 |
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