化工社化工社 化学情報印刷レポート · 研究参考用
Montelukast Sodium → Montelukast
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Montelukast Sodium | HCID 23663996 | — |
| 反応物 | Methyl 1-((acetylthio)methyl)cyclopropaneacetate | HCID 53482060 | — |
| 反応物 | 2-(2-(2-(3(S)-(3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-(methanesulfonyloxy)propyl)phenyl)-2-propoxy)tetrahydro pyran | HCID 54063535 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 溶媒 | Hydrazine | HCID 9321 | — |
| 溶媒 | Cesium carbonate | HCID 10796 | — |
| 溶媒 | Pyran | HCID 186148 | — |
| 生成物 | Montelukast | HCID 5281040 | — |
反応手順
EP 480717 discloses a process for preparing montelukast sodium by reacting 2-(2-(2-(3(S)-(3-(2-(7-chloro-2-quinolinyl)-ethenyl)phenyl)-3-(methanesulfonyloxy)propyl)phenyl)-2-propoxy)tetra hydro pyran with Methyl 1-(acetylthiomethyl)cyclopropane acetate in presence of hydrazine, cesium carbonate in acetonitrile as solvent to get methyl ester of Montelukast in pyran protected form, which is further reacted with pyridinium p-toluene sulfonate, sodium hydroxide in a mixture of methanol and tetrahydrofuran as a solvent to afford Montelukast sodium of Formula (I).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07189853B2 |
| 出典データセット | uspto-grants-2007_03 |
| ORD ID | ord-145bdb32b2424f22b2a88c4ad4ce5a7a |
| 出典メモ | uspto-grants-2007_03 |