関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Potassium Hydroxide | HCID 14797 | — |
| 反応物 | Ethyl-2-tert-butoxycarbonyloxyamino-4-methyl-thiazole-5-carboxylate | HCID 21911455 | — |
| 溶媒 | 2-(Oxolan-2-yl)ethan-1-ol | HCID 11989572 | — |
| 生成物 | 2-Tert-butoxycarbonyloxyamino-4-methyl-thiazole-5-carboxylic acid | HCID 21911430 | — |
反応手順
A stirred solution of ethyl-2-tert-butoxycarbonyloxyamino-4-methyl-thiazole-5-carboxylate (10 g, 34.95 mmol) in tetrahydrofuran-ethanol (250 mL, 2:3) was treated with a 6N KOH solution (250 mL). The mixture was heated to 55° C. overnight. The solution was cooled to 0° C. and acidified with concd. HCl to pH 1. The solvent was evaporated in vacuo. The residue was washed with water, diethyl ether, dried in vacuo over anhydrous phosphorous pentoxide to obtain the title acid (6 g, 89%) as a white solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US07189854B2 |
|---|
| 出典データセット | uspto-grants-2007_03 |
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| ORD ID | ord-26345d7f07bf4078993b2a1d11025717 |
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| 出典メモ | uspto-grants-2007_03 |
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