Hydrochloric Acid → 4-Chloromethyl-2-methoxy-1-pent-2-ynyloxy-benzene

HRID 458245ノート

反応式

HRID 458245 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:15]O)[CH:6]=[CH:7][C:8]=1[O:9][CH2:10][C:11]#[C:12][CH2:13][CH3:14].[ClH:17]>O1CCOCC1>[Cl:17][CH2:15][C:5]1[CH:6]=[CH:7][C:8]([O:9][CH2:10][C:11]#[C:12][CH2:13][CH3:14])=[C:3]([O:2][CH3:1])[CH:4]=1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 18442092(3-Methoxy-4-pent-2-ynyloxy-phenyl)-methanol

生成物 1

HCID 184420934-Chloromethyl-2-methoxy-1-pent-2-ynyloxy-benzene

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

A solution of (3-methoxy-4-pent-2-ynyloxy-phenyl)-methanol (27 g, 0.12 mol) in 450 ml of dioxan is added dropwise to 240 ml of concentrated hydrochloric acid. The reaction mixture is stirred for 1.5 hours at room temperature. Subsequently it is poured on water and extracted with ethyl acetate. The combined organic layer is washed with brine, dried over magnesium sulfate and evaporated in vacuo to obtain 4-chloromethyl-2-methoxy-1-pent-2-ynyloxy-benzene as yellow oil.

後処理

  1. additionSubsequently it is poured on water
  2. extractionextracted with ethyl acetate
  3. washThe combined organic layer is washed with brine
  4. dry with materialdried over magnesium sulfate
  5. customevaporated in vacuo

出典と根拠

ORDレコード
ord-7a630b6eee2b467e860d1d0089b0a612
出典データセット
uspto-grants-2007_03
特許番号
US07189873B2

反応ノート

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