化工社化工社 化学情報印刷レポート · 研究参考用
5-Amino-2-chlorobenzoic acid → 2-Chloro-5-(2,3,5,6-tetrafluoro-4-trifluoromethylbenzylamino)benzoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 5-Amino-2-chlorobenzoic acid | HCID 37879 | — |
| 反応物 | 4-(Trifluoromethyl)-2,3,5,6-tetrafluorobenzyl bromide | HCID 127137 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 2-Chloro-5-(2,3,5,6-tetrafluoro-4-trifluoromethylbenzylamino)benzoic acid | HCID 9978419 | 85.5% |
反応手順
According to the similar procedure in Synthesis Example 1, by using 5-amino-2-chlorobenzoic acid (1.02 g, 5.94 mmole) (ACROS, 32525-5000), DMF (50 ml) and 2,3,5,6-tetrafluoro-4-trifluoromethylbenzyl bromide (1.16 g, 6.99 mmole), 2.04 g (85.5% yield) of 2-chloro-5-(2,3,5,6-tetrafluoro-4-trifluoromethylbenzylamino)benzoic acid was obtained as a pale brown solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07189878B2 |
| 出典データセット | uspto-grants-2007_03 |
| ORD ID | ord-ebb0138070864df4ae3d54afbb204348 |
| 出典メモ | uspto-grants-2007_03 |