4-(Trifluoromethyl)-2,3,5,6-tetrafluorobenzyl bromide → 5-(2,3,5,6-Tetrafluoro-4-trifluoromethylbenzylamino)-2-trifluoromethoxybenzoic acid

HRID 458265ノート

反応式

HRID 458265 の反応式
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([O:11][C:12]([F:15])([F:14])[F:13])=[C:6]([CH:10]=1)[C:7]([OH:9])=[O:8].[F:16][C:17]1[C:24]([F:25])=[C:23]([C:26]([F:29])([F:28])[F:27])[C:22]([F:30])=[C:21]([F:31])[C:18]=1[CH2:19]Br>CN(C=O)C>[F:16][C:17]1[C:24]([F:25])=[C:23]([C:26]([F:29])([F:27])[F:28])[C:22]([F:30])=[C:21]([F:31])[C:18]=1[CH2:19][NH:1][C:2]1[CH:3]=[CH:4][C:5]([O:11][C:12]([F:13])([F:14])[F:15])=[C:6]([CH:10]=1)[C:7]([OH:9])=[O:8]

参加物

4

反応物 2

HCID 1271374-(Trifluoromethyl)-2,3,5,6-tetrafluorobenzyl bromideHCID 118309945-Amino-2-(trifluoromethoxy)benzoic acid

生成物 1

HCID 100494665-(2,3,5,6-Tetrafluoro-4-trifluoromethylbenzylamino)-2-trifluoromethoxybenzoic acid収率 81%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

According to the similar procedure in Synthesis Example 1, by using 5-amino-2-trifluoromethoxybenzoic acid (1.35 g, 6.23 mmole), DMF (50 ml), TEA (6 ml), and 2,3,5,6-tetrafluoro-4-trifluoromethylbenzyl bromide (1.10 ml, 6.73 mmole), 2.25 g (81.0% yield) of 5-(2,3,5,6-tetrafluoro-4-trifluoromethylbenzylamino)-2-trifluoromethoxybenzoic acid was obtained as a yellow solid.:

後処理

  1. customAccording to the similar procedure in Synthesis Example 1

出典と根拠

ORDレコード
ord-3ee3301dd9694704b236c3789af9fe89
出典データセット
uspto-grants-2007_03
特許番号
US07189878B2

反応ノート

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