2-(1,3-Dioxolan-2-yl)-1,3-thiazole-5-carboxylic acid → 2-Formylthiazole-5-carboxylic acid

HRID 458423ノート

反応式

HRID 458423 の反応式
[O:1]1CCO[CH:2]1[C:6]1[S:7][C:8]([C:11]([OH:13])=[O:12])=[CH:9][N:10]=1>Cl>[CH:2]([C:6]1[S:7][C:8]([C:11]([OH:13])=[O:12])=[CH:9][N:10]=1)=[O:1]

参加物

3

反応物 1

HCID 184418922-(1,3-Dioxolan-2-yl)-1,3-thiazole-5-carboxylic acid

生成物 1

HCID 184418962-Formylthiazole-5-carboxylic acid収率 91.4%

試薬・触媒・溶媒 1

HCID 313Hydrochloric Acid溶媒

実験手順

2-(1,3-dioxolan-2-yl)-1,3-thiazole-5-carboxylic acid (1.40 g, 6.96 mmol) was dissolved in 15 mL of 6N HCl and heated to reflux for 30 min and then cooled to ambient temperature. The organics were extracted twice with EtOAc and then dried(Na2SO4), filtered and concentrated to give the title compound (1.00 g, 6.36 mmol, 91% yield) as an orange solid. 1H NMR (CDCl3, 400 MHz) δ 10.0 (s, 1H), 8.66 (s, 1H), 6.70–6.00 (bs, 1H).

後処理

  1. temperatureheated
  2. temperatureto reflux for 30 min
  3. extractionThe organics were extracted twice with EtOAc
  4. filtrationdried(Na2SO4), filtered
  5. concentrationconcentrated

出典と根拠

ORDレコード
ord-b805159e456a4d82a2ccd748f1b83963
出典データセット
uspto-grants-2007_03
特許番号
US07189851B2

反応ノート

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