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4-Octoxybenzoyl hydrazine → 3,5-dibromo-N'-[4-(octyloxy)benzoyl]benzohydrazide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Octoxybenzoyl hydrazine | HCID 4281533 | — |
| 反応物 | 3,5-Dibromobenzoyl chloride | HCID 13450526 | — |
| 反応物 | 2-(2,5-Dibromophenyl)-5-[4-(octyloxy)phenyl]-1,3,4-oxadiazole | HCID 21982073 | — |
| 生成物 | 3,5-dibromo-N'-[4-(octyloxy)benzoyl]benzohydrazide | HCID 21982081 | 36% |
反応手順
By the general method for the synthesis of 2-(2,5-dibromophenyl)-5-[4-(octyloxy)phenyl]-1,3,4-oxadiazole in Example 1, the reaction of 3,5-dibromobenzoyl chloride (20.13 g, 0.06747 mole) with 4-octyloxybenzoic acid hydrazide (17 g, 0.06747 mole) gave the intermediate 3,5-dibromo-N′-[4-(octyloxy)benzoyl]benzohydrazide (12.87 g, 36% yield). Cyclocondensation of the intermediate 3,5-dibromo-N′-[4-(octyloxy)benzoyl]-benzohydrazide (12.17 g) with POCl3 (63 mL) gave the required 2-(3,5-dibromophenyl)-5-[4-(octyloxy)phenyl]-1,3,4-oxadiazole (6.12 g, 52% yield).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07192657B2 |
| 出典データセット | uspto-grants-2007_03 |
| ORD ID | ord-def7b1a82ede453eb42287d0f43d1b25 |
| 出典メモ | uspto-grants-2007_03 |