Water → 1',3'-Dihydrospiro[imidazolidine-4,2'-indene]-2,5-dione
反応式
[CH2:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][C:2]1=O.[C-:11]#[N:12].[Na+].[C:14](=[O:17])([O-])[O-].[NH4+:18].[NH4+].[OH2:20]>CCO>[CH2:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][C:2]21[C:11](=[O:20])[NH:12][C:14](=[O:17])[NH:18]2参加物
6
反応条件
- 温度
- 70 °C
実験手順
A stirred mixture of 2-indanone (3.0 g, 22.6 mmol), sodium cyanide (3.3 g, 67.3 mmol), and ammonium carbonate (22 g, 228 mol) in H2O (50 mL) and EtOH (50 mL) was heated to 70° C. for 3 h, then allowed to cool to ambient temperature. The precipitate was collected by filtration and washed with H2O (5×100 mL). Drying in vacuo afforded the title compound as a gray-brown solid. MS: m/z=202 (M+1).
後処理
- temperatureto cool to ambient temperature
- filtrationThe precipitate was collected by filtration
- washwashed with H2O (5×100 mL)
- customDrying in vacuo
出典と根拠
- ORDレコード
- ord-c2743ebef5cc490995840081776d5b1f
- 出典データセット
- uspto-grants-2007_03
- 特許番号
- US07192954B2
反応ノート
読み込み中…