関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Ethyl Acetate | HCID 8857 | — |
| 反応物 | 8-Chlorotheophylline | HCID 10661 | — |
| 反応物 | 2-Bromobenzyl bromide | HCID 76965 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 溶媒 | Diisopropylethylamine | HCID 81531 | — |
| 生成物 | Purine-2,6(1H,3H)-dione, 7-(2-bromobenzyl)-8-chloro-1,3-dimethyl- | HCID 598207 | — |
反応手順
8-Chlorotheophylline (10 g, 46.6 mmol) was dissolved in 250 ml of DMF and 8 ml of DIEA, and 2-bromobenzyl bromide (12.2 g, 48.9 mmol) was added. The mixture was stirred at 65° C. for 2 hours. The reaction mixture was added 20 ml of EtOAc and 250 ml of cold water. The white precipitate was collected by filtration to afford compound (10A) as white crystals.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07192952B2 |
|---|
| 出典データセット | uspto-grants-2007_03 |
|---|
| ORD ID | ord-e6f9c7aad5964e9089d97203461a5454 |
|---|
| 出典メモ | uspto-grants-2007_03 |
|---|
