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Dichloromethane → 3-(4-Benzyloxy-3-methoxy-phenyl)-propionic acid benzyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dichloromethane | HCID 6344 | — |
| 反応物 | Benzyl Bromide | HCID 7498 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | Dihydroferulic Acid | HCID 14340 | — |
| 溶媒 | Acetone | HCID 180 | — |
| 生成物 | 3-(4-Benzyloxy-3-methoxy-phenyl)-propionic acid benzyl ester | HCID 69353460 | 180.5% |
反応手順
A mixture of 3-(4-hydroxy-3-methoxy-phenyl)-propionic acid (5.1 g, 25.99 mmol), anhydrous K2CO3 (25 g, 180.88 mmol) and benzyl bromide (7.5 ml, 63.14 mmol) in anhydrous acetone (100 ml) was stirred at reflux for 7.5 h under nitrogen. After cooling, the reaction mixture was filtered and concentrated in vacuo. Flash chromatography (CH2Cl2) gave the title compound (8.83 g, 23.45 mmol, 90%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07192950B2 |
| 出典データセット | uspto-grants-2007_03 |
| ORD ID | ord-7466c945d5f9454a84cc85d0aed68e9a |
| 出典メモ | uspto-grants-2007_03 |