Methyl alpha-hydroxy-alpha-2-thienyl-2-thiopheneacetate → 2-Hydroxy-2,2-dithien-2-ylacetic acid (3R)-1-(3-thien-2-ylpropyl)pyrrolidin-3-yl ester
反応式
[CH3:1][O:2][C:3](=[O:16])[C:4]([OH:15])([C:10]1[S:11][CH:12]=[CH:13][CH:14]=1)[C:5]1[S:6][CH:7]=[CH:8][CH:9]=1.[S:17]1[CH:21]=[CH:20][CH:19]=[C:18]1[CH2:22][CH2:23][CH2:24][N:25]1[CH2:29]C[C@@H:27](O)[CH2:26]1>>[S:17]1[CH:21]=[CH:20][CH:19]=[C:18]1[CH2:22][CH2:23][CH2:24][N:25]1[CH2:26][CH2:27][C@@H:1]([O:2][C:3](=[O:16])[C:4]([OH:15])([C:5]2[S:6][CH:7]=[CH:8][CH:9]=2)[C:10]2[S:11][CH:12]=[CH:13][CH:14]=2)[CH2:29]1参加物
3
実験手順
Prepared as described in Intermediate I-1 from 2-Hydroxy-2,2-dithien-2-ylacetic acid methyl ester and (3R)-1-(3-thien-2-ylpropyl)pyrrolidin-3-ol (Intermediate I-17). The yield was 0.83 g (49.1%) of the title product as an oil. A portion of this product was solidified by formation of the oxalate salt.
後処理
- customPrepared