3-Hydroxy-N-phenylaniline → (2s)-2-Methoxy-3-{4-[3-(3-phenylamino-phenoxy)-prop-1-ynyl]-phenyl}-propionic acid

HRID 459081

反応式

HRID 459081 の反応式
C([O:3][C:4](=[O:19])[C@@H:5]([O:17][CH3:18])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([C:13]#[C:14][CH2:15]Cl)=[CH:9][CH:8]=1)C.[CH:20]1[CH:25]=[CH:24][C:23]([NH:26][C:27]2[CH:32]=[CH:31][CH:30]=[C:29]([OH:33])[CH:28]=2)=[CH:22][CH:21]=1>>[CH3:18][O:17][C@@H:5]([CH2:6][C:7]1[CH:8]=[CH:9][C:10]([C:13]#[C:14][CH2:15][O:33][C:29]2[CH:30]=[CH:31][CH:32]=[C:27]([NH:26][C:23]3[CH:22]=[CH:21][CH:20]=[CH:25][CH:24]=3)[CH:28]=2)=[CH:11][CH:12]=1)[C:4]([OH:3])=[O:19]

参加物

3

反応物 2

HCID 75463-Hydroxy-N-phenylanilineHCID 58822943(2S)-3-[4-(3-Chloro-prop-1-ynyl)-phenyl]-2-methoxy-propionic acid ethyl ester

生成物 1

HCID 58822707(2s)-2-Methoxy-3-{4-[3-(3-phenylamino-phenoxy)-prop-1-ynyl]-phenyl}-propionic acid

実験手順

The title compound was prepare from (2S)-3-[4-(3-Chloro-prop-1-ynyl)-phenyl]-2-methoxy-propionic acid ethyl ester from Example 5, Step A and 3-hydroxydiphenylamine in a manner analogous to that described for Example 5, Step B. MS(ES) for CH23H23NO [M+H]+: 402.2.

出典と根拠

ORDレコード
ord-6df4cda6654a40c59f6f4bd4ac1f0d91
出典データセット
uspto-grants-2007_03
特許番号
US07192982B2

関連ノート

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