6-Hydroxyflavone → (2S)-2-Methoxy-3-{4-[5-(4-oxo-2-phenyl-4H-chromen-6-yloxy)-pent-1-ynyl]-phenyl}-propionic acid

HRID 459096

反応式

HRID 459096 の反応式
C([O:3][C:4](=[O:21])[CH:5]([O:19][CH3:20])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([C:13]#[C:14][CH2:15][CH2:16][CH2:17]Br)=[CH:9][CH:8]=1)C.[OH:22][C:23]1[CH:24]=[C:25]2[C:30](=[CH:31][CH:32]=1)[O:29][C:28]([C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1)=[CH:27][C:26]2=[O:39]>>[CH3:20][O:19][C@@H:5]([CH2:6][C:7]1[CH:8]=[CH:9][C:10]([C:13]#[C:14][CH2:15][CH2:16][CH2:17][O:22][C:23]2[CH:24]=[C:25]3[C:30](=[CH:31][CH:32]=2)[O:29][C:28]([C:33]2[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=2)=[CH:27][C:26]3=[O:39])=[CH:11][CH:12]=1)[C:4]([OH:3])=[O:21]

参加物

3

反応物 2

HCID 722796-HydroxyflavoneHCID 694219733-[4-(5-Bromo-pent-1-ynyl)-phenyl]-2-methoxy-propionic acid ethyl ester

生成物 1

HCID 58822631(2S)-2-Methoxy-3-{4-[5-(4-oxo-2-phenyl-4H-chromen-6-yloxy)-pent-1-ynyl]-phenyl}-propionic acid

実験手順

The title compound was prepared from 3-[4-(5-Bromo-pent-1-ynyl)-phenyl]-2-methoxy-propionic acid ethyl ester from Example 24, Step A and 6-hydroxyflavone in a manner analogous to that described for Example 24, Step B. MS(ES) for C30H26O6[M+H]+:483.2

出典と根拠

ORDレコード
ord-bee694d5e8d6403c9885275e490a9db3
出典データセット
uspto-grants-2007_03
特許番号
US07192982B2

関連ノート

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