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7-Hydroxyflavone → (2S)-2-Methoxy-3-{4-[3-(4-oxo-2-phenyl-4H-chromen-7-yloxy)-propoxy]-phenyl}-propionic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 7-Hydroxyflavone | HCID 5281894 | — |
| 反応物 | (2S)-3-[4-(3-Hydroxy-propoxy)-phenyl]-2-methoxy-propionic acid | HCID 69424952 | — |
| 生成物 | (2S)-2-Methoxy-3-{4-[3-(4-oxo-2-phenyl-4H-chromen-7-yloxy)-propoxy]-phenyl}-propionic acid | HCID 58822836 | — |
反応手順
The title compound was prepared from (2S)-3-[4-(3-Hydroxy-propoxy)-phenyl]-2-methoxy-propionic acid linked to Wang's Resin (Example 94, Step D) via Mitsunobu coupling with 7-hydroxyflavone and cleavage from the resin (Standard Procedure G) gave an oily solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07192982B2 |
| 出典データセット | uspto-grants-2007_03 |
| ORD ID | ord-7a4feb1f8f80404081c313555e183b4e |
| 出典メモ | uspto-grants-2007_03 |