Carbon tetrabromide → 3-{4-[3-(3-Allyl-biphenyl-4-yloxy)-propoxy]-phenyl}-2-methoxy-propionic acid ethyl ester

HRID 459176ノート

反応式

HRID 459176 の反応式
[CH2:1]([C:4]1[CH:5]=[C:6]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH:7]=[CH:8][C:9]=1[O:10][CH2:11][CH2:12][CH2:13][OH:14])[CH:2]=[CH2:3].C(Br)(Br)(Br)Br.C1C=CC(P(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.[CH2:45]([O:47][C:48](=[O:60])[C@@H:49]([O:58][CH3:59])[CH2:50][C:51]1[CH:56]=[CH:55][C:54](O)=[CH:53][CH:52]=1)[CH3:46]>ClCCl>[CH2:45]([O:47][C:48](=[O:60])[CH:49]([O:58][CH3:59])[CH2:50][C:51]1[CH:56]=[CH:55][C:54]([O:14][CH2:13][CH2:12][CH2:11][O:10][C:9]2[CH:8]=[CH:7][C:6]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)=[CH:5][C:4]=2[CH2:1][CH:2]=[CH2:3])=[CH:53][CH:52]=1)[CH3:46]

参加物

6

反応物 4

HCID 11205Carbon tetrabromideHCID 11776TriphenylphosphineHCID 11390460(2S)-3-(4-hydroxy-phenyl)-2-methoxypropionic acid ethyl esterHCID 184436063-(3-Allyl-biphenyl-4-yloxy)-propan-1-ol

生成物 1

HCID 694229003-{4-[3-(3-Allyl-biphenyl-4-yloxy)-propoxy]-phenyl}-2-methoxy-propionic acid ethyl ester

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A solution of compound from Step B in dichloromethane was treated with CBr4 (1.12 eq) and PPh3 (1.4 eq) and allow to react for 1.5 hours. The product isolated after chromatography of this reaction was treated under Standard Procedure I with (2S)-3-(4-hydroxy-phenyl)-2-methoxy-propionic acid ethyl ester to give the title compound.

後処理

  1. customto react for 1.5 hours
  2. customThe product isolated after chromatography of this reaction

出典と根拠

ORDレコード
ord-cf5cdbbb851f485496c6cb2e8a0b4829
出典データセット
uspto-grants-2007_03
特許番号
US07192982B2

反応ノート

読み込み中…