6-Hydroxyflavone → 2-Methoxy-3-{3-methoxy-4-[3-(4-oxo-2-phenyl-4H-chromen-6-yloxy)-propoxy]-phenyl}-propionic acid
反応式
Br[CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([CH2:12][CH:13]([O:17][CH3:18])[C:14]([OH:16])=[O:15])=[CH:8][C:7]=1[O:19][CH3:20].[OH:21][C:22]1[CH:23]=[C:24]2[C:29](=[CH:30][CH:31]=1)[O:28][C:27]([C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1)=[CH:26][C:25]2=[O:38]>>[CH3:18][O:17][CH:13]([CH2:12][C:9]1[CH:10]=[CH:11][C:6]([O:5][CH2:4][CH2:3][CH2:2][O:21][C:22]2[CH:23]=[C:24]3[C:29](=[CH:30][CH:31]=2)[O:28][C:27]([C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=2)=[CH:26][C:25]3=[O:38])=[C:7]([O:19][CH3:20])[CH:8]=1)[C:14]([OH:16])=[O:15]参加物
3
実験手順
The title compound was prepared from 3-[4-(3-Bromo-propoxy)-3-methoxy-phenyl]-2-methoxy-propionic acid (Example 175, Step B) and 6-Hydroxy-2-phenyl-chromen-4-one following the Standard Procedure J. 1H-NMR (200.15 MHz, CDCl3): 8.0–7.9 (m, 2H), 7.6–7.5 (m, 5H), 7.30 (dd, 1H, J=9.0, 3.0), 6.9–6.8 (m, 4H), 4.3–4.2 (m, 4H), 4.00 (dd, 1H, J=7.2, 4.6), 3.83 (s, 3H), 3.41 (s, 3H), 3.09 (dd, 1H, J=14.2, 4.6), 2.96 (dd, 1H, J=14.2, 7.2), 2.33 (qn, 2H, J=6.2) ppm.
出典と根拠
- ORDレコード
- ord-4e585c74bc6242df889a1c2593354c54
- 出典データセット
- uspto-grants-2007_03
- 特許番号
- US07192982B2
反応ノート
読み込み中…