2-Methyl-1,3-benzothiazol-5-ol → (2S)-2-Methoxy-3-{4-[3-(2-methyl-benzothiazol-5-yloxy)-propoxy]-phenyl}-propionic acid

HRID 459306

反応式

HRID 459306 の反応式
C([O:3][C:4](=[O:20])[C@@H:5]([O:18][CH3:19])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH2:14][CH2:15][CH2:16]Br)=[CH:9][CH:8]=1)C.[CH3:21][C:22]1[S:23][C:24]2[CH:30]=[CH:29][C:28]([OH:31])=[CH:27][C:25]=2[N:26]=1.CO[C@@H](CC1C=CC(OCCCOC2C=CC=CC=2)=CC=1)C(O)=O>>[CH3:19][O:18][C@@H:5]([CH2:6][C:7]1[CH:8]=[CH:9][C:10]([O:13][CH2:14][CH2:15][CH2:16][O:31][C:28]2[CH:29]=[CH:30][C:24]3[S:23][C:22]([CH3:21])=[N:26][C:25]=3[CH:27]=2)=[CH:11][CH:12]=1)[C:4]([OH:3])=[O:20]

参加物

4

反応物 3

HCID 6997992-Methyl-1,3-benzothiazol-5-olHCID 58822859(2S)-3-[4-(3-Bromopropoxy)-phenyl]-2-methoxy-propionic acid ethyl esterHCID 58822897(2S)-2-methoxy-3-[4-(3-phenoxy propoxy)-phenyl]-propionic acid

生成物 1

HCID 58822649(2S)-2-Methoxy-3-{4-[3-(2-methyl-benzothiazol-5-yloxy)-propoxy]-phenyl}-propionic acid

実験手順

The title compound was prepared from (2S)-3-[4-(3-bromo-propoxy)-phenyl]-2-methoxy-propionic acid ethyl ester (Example 284, Step 2) and 2-methyl-benzothiazol-5-ol via the same procedure used for the preparation of (2S)-2-methoxy-3-[4-(3-phenoxy-propoxy)-phenyl]-propionic acid Example 285, Step 1), to produce a colorless oil.

後処理

  1. customto produce a colorless oil

出典と根拠

ORDレコード
ord-5d02057877064b06ab27d5523a5e494b
出典データセット
uspto-grants-2007_03
特許番号
US07192982B2

関連ノート

読み込み中…