2-Isopropylphenol → 3-{3-[3-(2-Isopropyl-phenoxy)-propoxy]-phenyl}-2-methoxy-propionic acid
反応式
C[O:2][C:3](=[O:19])[CH:4]([O:17][CH3:18])[CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([O:12][CH2:13][CH2:14][CH2:15]Br)[CH:7]=1.[CH:20]([C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=1[OH:29])([CH3:22])[CH3:21].CO[C@@H](CC1C=CC(OCCCOC2C=CC=CC=2)=CC=1)C(O)=O>>[CH:20]([C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=1[O:29][CH2:15][CH2:14][CH2:13][O:12][C:8]1[CH:7]=[C:6]([CH2:5][CH:4]([O:17][CH3:18])[C:3]([OH:2])=[O:19])[CH:11]=[CH:10][CH:9]=1)([CH3:22])[CH3:21]参加物
4
実験手順
The title compound-was prepared from 3-[3-(3-bromo-propoxy)-phenyl]-2-methoxy-propionic acid methyl ester (Example 323, Step 1) and 2-isopropylphenol via the same procedure used for the preparation of (2S)-2-methoxy-3-[4-(3-phenoxy-propoxy)-phenyl]-propionic acid (Example 285, Step 1). The enatiomers were separated by chiral HPLC. MS (ES) for C22H28O5 [M+Na]+: 395.4.
後処理
- customThe enatiomers were separated by chiral HPLC
出典と根拠
- ORDレコード
- ord-cac34ed447164ce683800b34054a8ef1
- 出典データセット
- uspto-grants-2007_03
- 特許番号
- US07192982B2
反応ノート
読み込み中…