3-Fluorophenol → 3-{3-[2-(3-Fluoro-phenoxy)-ethoxy]-phenyl}-2-methoxy-propionic acid

HRID 459373

反応式

HRID 459373 の反応式
[F:1][C:2]1[CH:3]=[C:4]([OH:8])[CH:5]=[CH:6][CH:7]=1.C[O:10][C:11](=[O:26])[CH:12]([O:24][CH3:25])[CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[C:16]([O:20][CH2:21][CH2:22]Br)[CH:15]=1.CO[C@@H](CC1C=CC(OCCCOC2C=CC=CC=2)=CC=1)C(O)=O>>[F:1][C:2]1[CH:3]=[C:4]([CH:5]=[CH:6][CH:7]=1)[O:8][CH2:22][CH2:21][O:20][C:16]1[CH:15]=[C:14]([CH2:13][CH:12]([O:24][CH3:25])[C:11]([OH:26])=[O:10])[CH:19]=[CH:18][CH:17]=1

参加物

4

反応物 3

HCID 97433-FluorophenolHCID 58822897(2S)-2-methoxy-3-[4-(3-phenoxy propoxy)-phenyl]-propionic acidHCID 694234133-[3-(2-Bromo-ethoxy)-phenyl]-2-methoxy-propionic acid methyl ester

生成物 1

HCID 184435893-{3-[2-(3-Fluoro-phenoxy)-ethoxy]-phenyl}-2-methoxy-propionic acid

実験手順

The title compound was prepared from 3-fluoro-phenol and 3-[3-(2-bromo-ethoxy)-phenyl]-2-methoxy-propionic acid methyl ester (Example 351, Step 1) via the same procedure used for the preparation of (2S)-2-methoxy-3-[4-(3-phenoxy-propoxy)-phenyl]-propionic acid (Example 285, Step 1). The enatiomers were separated by chiral HPLC. MS (ES) for C18H19FO5 [M−H]−: 333.1.

後処理

  1. customThe enatiomers were separated by chiral HPLC

出典と根拠

ORDレコード
ord-33298014baf84261bd8295c3660907ca
出典データセット
uspto-grants-2007_03
特許番号
US07192982B2

関連ノート

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