2-(Pyrrolidin-1-yl)phenol → (2S)-2-methoxy-3-{4-[2-(2-pyrrolidin-1-yl-phenoxy)-ethoxy]-phenyl}-propionic acid
反応式
C([O:3][C:4](=[O:19])[C@@H:5]([O:17][CH3:18])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH2:14][CH2:15]Br)=[CH:9][CH:8]=1)C.[N:20]1([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=2[OH:31])[CH2:24][CH2:23][CH2:22][CH2:21]1.CO[C@@H](CC1C=CC(OCCCOC2C=CC=CC=2)=CC=1)C(O)=O>>[CH3:18][O:17][C@@H:5]([CH2:6][C:7]1[CH:8]=[CH:9][C:10]([O:13][CH2:14][CH2:15][O:31][C:26]2[CH:27]=[CH:28][CH:29]=[CH:30][C:25]=2[N:20]2[CH2:24][CH2:23][CH2:22][CH2:21]2)=[CH:11][CH:12]=1)[C:4]([OH:3])=[O:19]参加物
4
実験手順
The title compound was prepared from (2S)-3-[4-(2-bromo-ethoxy)-phenyl]-2-methoxy-propionic acid ethyl ester (Example 283, Step 2) and 2-pyrrolidin-1-yl-phenol via the same procedure used for the preparation of (2S)-2-methoxy-3-[4-(3-phenoxy-propoxy)-phenyl]-propionic acid (Example 285, Step 1), to produce a yellow oil.